RNA toxicity and perturbation of rRNA processing in spinocerebellar ataxia type 2
Pan P. Li, Roumita Moulick, Hongxuan Feng, Xin Sun, Nicolas Arbez, Jing Jin, Leonard O. Marque, Erin Hedglen, Ho Yin Edwin Chan, Christopher A. Ross, Stefan M. Pulst, Russell L. Margolis, Sarah A. Woodson, Dobrila D. Rudnicki
This study shows that expanded ATXN2 transcripts are toxic and disrupt rRNA processing in SCA2, similar to expanded HTT transcripts in HD, suggesting a shared mechanism in repeat expansion diseases.
Movement Disorders · Aug 14, 2021Peer-reviewedNeuroscience