Ho Yin Edwin Chan

This paper develops a programmable mRNA platform that detects specific miRNAs by converting their presence into a quantifiable protein output through miRNA-triggered ribosomal frameshifting.

This study identifies FasII upregulation as a key factor in DM1 neuropathology using a Drosophila model, showing that manipulating FasII isoforms can rescue synaptic and behavioral defects.

This study shows that expanded ATXN2 transcripts are toxic and disrupt rRNA processing in SCA2, similar to expanded HTT transcripts in HD, suggesting a shared mechanism in repeat expansion diseases.

This study identifies zonation-dependent transcriptomic changes in aged brain endothelial cells, highlighting functional impacts on the BBB and AD-associated genes, and shows reversal with GLP-1R agonist treatment.