Russell L. Margolis

BlueNuclei automates the identification and classification of live and dead transfected neurons using interpretable features, achieving near-human accuracy with faster processing than deep learning alternatives.

This study identifies bidirectional transcription at the PPP2R2B gene locus in SCA12 and shows that expanded antisense transcripts are toxic and contribute to disease pathogenesis.

This study shows that expanded ATXN2 transcripts are toxic and disrupt rRNA processing in SCA2, similar to expanded HTT transcripts in HD, suggesting a shared mechanism in repeat expansion diseases.