Single-molecule sequencing and conformational capture enable de novo mammalian reference genomes
Derek M Bickhart, Benjamin D Rosen, Sergey Koren, Brian L Sayre, Alex R Hastie, Saki Chan, Joyce Lee, Ernest T Lam, Ivan Liachko, Shawn T Sullivan, Joshua N Burton, Heather J Huson, Christy M Kelley, Jana L Hutchison, Yang Zhou, , Timothy P.L. Smith
This paper presents a de novo mammalian genome assembly for the domestic goat using long-read sequencing, short-read validation, and chromatin interaction mapping, achieving high contiguity and resolving repetitive regions.
bioRxiv · Jul 18, 2016Genomics