Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells
William Lucas P Wadley, Helen Q. Huang, Hew Yeng Lai, Jianhong C Heidmann, Jane Chen, Eli M. Soyfer, Kalei Guillermo, Eshika Arora, Lauren Chen, Brianna Hoover, Angela G. Fleischman
This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.
bioRxiv · Sep 30, 2025 · PreprintCell Biology