Author

Lauren Chen

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Angela G. FleischmaniD· 1 shared Brianna HooveriD· 1 shared Eli M. SoyferiD· 1 shared Eshika Arora· 1 shared Helen Q. Huang· 1 shared Hew Yeng LaiiD· 1 shared Jane Chen· 1 shared Jianhong C Heidmann· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

Angela G. FleischmanORCID

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1 paper

Recent·Most cited

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

William Lucas P Wadley, Helen Q. Huang, Hew Yeng Lai, Jianhong C Heidmann, Jane Chen, Eli M. Soyfer, Kalei Guillermo, Eshika Arora, Lauren Chen, Brianna Hoover, Angela G. Fleischman

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

bioRxiv · Sep 30, 2025 · PreprintCell Biology