Angela G. Fleischman

Clonal hematopoiesis-associated DNMT3A mutations derepress bivalent Polycomb target genes and enhance macrophage migration

Cigarette Smoke and E-Cigarette Aerosol Extracts Induce Myelopoiesis and Suppress Inflammatory Cytokine Production

This study shows that cigarette smoke and e-cigarette aerosol extracts suppress inflammatory cytokine production and induce myelopoiesis, leading to hematopoietic aging.

Hierarchical tissue structure creates history-dependent barriers to clonal invasion

The paper shows that hierarchical tissue structure creates history-dependent barriers to clonal invasion, with established clones affecting the invasion thresholds for subsequent mutants.

Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate

This study shows pitavastatin overcomes venetoclax resistance in AML by depleting GGPP, inducing apoptosis through PUMA upregulation and MCL-1 reduction, and suppressing mitochondrial metabolism.

Impaired IL-10 Receptor Signaling Leads to Inflammation Induced Exhaustion in Hematopoietic Stem Cells

This study shows that IL-10 receptor signaling prevents inflammation-induced hematopoietic stem cell exhaustion, and its blockade accelerates aging and promotes clonal expansion of Jak2V617F mutant HSCs.

Multimodal gene and targeted drug therapy for chronic myelogenous leukemia: Computational target analysis and therapeutic validation

This paper develops a multimodal therapy for CML combining computational target analysis with nanoparticle-based drug delivery and validates its efficacy in mouse models.