Developmental BiologybioRxivPreprint
A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes
Haiting Ma, Esmée de Zwaan, Yang Eric Guo…·Rudolf Jaenisch
This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.
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