Author

Carrie M. Garrett-Engele

Whitehead Institute for Biomedical Research

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Developmental Biology· 1

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:ATAC-seq· 1 Research Focus:cell type annotation· 1 Assay:ChIP-seq· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Dongdong FuiD· 3 shared Rudolf JaenischiD· 3 shared Bingbing YuaniD· 2 shared Kristin R. Andrykovich· 2 shared Marine KrzischiD· 2 shared Mriganka SuriD· 2 shared Aaron N. Chang· 1 shared Alessandra Dall’AgneseiD· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersNeuroscience

Dongdong FuORCID

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3 papers

Recent·Most cited

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia

Marine Krzisch, Bingbing Yuan, Wenyu Chen, Tatsuya Osaki, Dongdong Fu, Carrie M. Garrett-Engele, Devon S. Svoboda, Kristin R. Andrykovich, Mriganka Sur, Rudolf Jaenisch

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

bioRxiv · Aug 29, 2023 · PreprintNeuroscience

Fragile X syndrome patient-derived neurons developing in the mouse brain show FMR1 -dependent phenotypes

Marine Krzisch, Hao Wu, Bingbing Yuan, Troy W. Whitfield, X. Shawn Liu, Dongdong Fu, Carrie M. Garrett-Engele, Andrew S. Khalil, Tenzin Lungjangwa, Jennifer Shih, Aaron N. Chang, Stephen T. Warren, Angela M. Cacace, Kristin R. Andrykovich, Rosalie G. J. Rietjens, , Rudolf Jaenisch

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

Biological Psychiatry · Jan 1, 2023Peer-reviewedNeuroscience

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

Haiting Ma, Esmée de Zwaan, Yang Eric Guo, Paloma Cejas, Prathapan Thiru, Martijn van de Bunt, Jacob Fuglsbjerg Jeppesen, Sudeepa Syamala, Alessandra Dall’Agnese, Brian J. Abraham, Dongdong Fu, Carrie M. Garrett-Engele, Tony Lee, Henry W. Long, Linda Gay Griffith, , Rudolf Jaenisch

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.

bioRxiv · Mar 24, 2022 · PreprintDevelopmental Biology