Dongdong Fu

The A53T mutation in α-synuclein enhances pro-inflammatory activation in human microglia

This study shows that the A53T mutation in α-synuclein increases pro-inflammatory activation and oxidative stress in human microglia, potentially contributing to early-onset Parkinson's disease.

Fragile X syndrome patient-derived neurons developing in the mouse brain show FMR1 -dependent phenotypes

This study transplants FXS patient-derived neurons into mice to study their development and finds FMR1-dependent changes in synaptic activity and morphology.

A nuclear receptor facilitates differentiation of human PSCs into more mature hepatocytes

This study identifies thyroid hormone receptor THRB as a key regulator of hepatocyte maturation from human PSCs, showing that T3 treatment enhances gene expression and epigenetic features of mature hepatocytes.