Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming
Riya Keshri, Zachary Foreman, Philip Barrett, Alexander J. Robinson, Gabriela Reyes, Ashish Phal, Aditya Krishnakumar, Ethan Narog, Melodie Chiu, Shruti Jain, Xinru Wang, David J. Lee, Marc Expòsit, Mohamad H. Abedi, Alec S.T. Smith, , Hannele Ruohola‐Baker
This paper demonstrates that AI-designed receptor modulators can drive efficient human fibroblast-to-muscle transdifferentiation by rewiring extracellular signaling.
bioRxiv · Apr 27, 2026 · PreprintBiochemistry