Author

Riya Keshri

University of WashingtonORCID 0000-0001-7708-6402Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

David A. BakeriD· 3 shared Hannele Ruohola‐BakeriD· 3 shared Marc ExpòsitiD· 3 shared Mohamad H. AbediiD· 3 shared Aditya KrishnakumariD· 2 shared Alec S.T. SmithiD· 2 shared Ashish PhaliD· 2 shared Brian CoventryiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

David A. BakerORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming

Riya Keshri, Zachary Foreman, Philip Barrett, Alexander J. Robinson, Gabriela Reyes, Ashish Phal, Aditya Krishnakumar, Ethan Narog, Melodie Chiu, Shruti Jain, Xinru Wang, David J. Lee, Marc Expòsit, Mohamad H. Abedi, Alec S.T. Smith, , Hannele Ruohola‐Baker

This paper demonstrates that AI-designed receptor modulators can drive efficient human fibroblast-to-muscle transdifferentiation by rewiring extracellular signaling.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry

High-Throughput De Novo Protein Design Yields Novel Immunomodulatory Agonists

Mohamad H. Abedi, Marc Expòsit, Brian Coventry, Divij Mathew, Shruti Jain, Aditya Krishnakumar, Inna Goreshnik, Sophie L. Gray-Gaillard, Margaret C. Lunn-Halbert, Ta-Yi Yu, Matthias Glögl, Uma Mitchell, Riya Keshri, Jung-Ho Chun, Hannele Ruohola‐Baker, , David A. Baker

The paper designs novel cytokines by fusing computationally generated receptor-binding domains, identifying several that activate signaling pathways and have specific biological effects.

bioRxiv · Oct 12, 2025 · PreprintSynthetic Biology

Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity

Riya Keshri, Marc Expòsit, Mohamad H. Abedi, Derrick R. Hicks, Zachary Foreman, Ashish Phal, Yen Chian Lim, Philip Barrett, Catherine M Sniezek, Jinlong Lin, Thomas Schlichthaerle, Alexander Robinson, Damien Detraux, Tung Chan Ching, Keija Wu, , Hannele Ruohola‐Baker

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

bioRxiv · Oct 12, 2025 · PreprintBiochemistry