Author

Zachary Foreman

University of Washington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Ashish PhaliD· 3 shared Hannele Ruohola‐BakeriD· 3 shared Julie MathieuiD· 3 shared Alec S.T. SmithiD· 2 shared David A. BakeriD· 2 shared David L. MackiD· 2 shared Marc ExpòsitiD· 2 shared Mohamad H. AbediiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersBiochemistry

Ashish PhalORCID

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Author profile →

3 papers

Recent·Most cited

Designed Minibinders Rewire Receptor Signaling to Enable Functional Human Myogenic Reprogramming

Riya Keshri, Zachary Foreman, Philip Barrett, Alexander J. Robinson, Gabriela Reyes, Ashish Phal, Aditya Krishnakumar, Ethan Narog, Melodie Chiu, Shruti Jain, Xinru Wang, David J. Lee, Marc Expòsit, Mohamad H. Abedi, Alec S.T. Smith, , Hannele Ruohola‐Baker

This paper demonstrates that AI-designed receptor modulators can drive efficient human fibroblast-to-muscle transdifferentiation by rewiring extracellular signaling.

bioRxiv · Apr 27, 2026 · PreprintBiochemistry

Direct cell reprogramming by a designed agonist inducing HER2-FGFR proximity

Riya Keshri, Marc Expòsit, Mohamad H. Abedi, Derrick R. Hicks, Zachary Foreman, Ashish Phal, Yen Chian Lim, Philip Barrett, Catherine M Sniezek, Jinlong Lin, Thomas Schlichthaerle, Alexander Robinson, Damien Detraux, Tung Chan Ching, Keija Wu, , Hannele Ruohola‐Baker

This paper designs a synthetic ligand, H2F, that induces HER2-FGFR proximity to reprogram fibroblasts into myogenic cells and promote myogenic regeneration.

bioRxiv · Oct 12, 2025 · PreprintBiochemistry

Human iPSC-derived salivary gland organoids model diabetic salivary gland dysfunction

Devon Duron Ehnes, Akira Morishita, Ashish Phal, Hee Yun Jung, Yen Chian Lim, Zachary Foreman, Vincenzo Cirulli, Julie Mathieu, Hannele Ruohola‐Baker

This study develops human iPSC-derived salivary gland organoids that model diabetic dysfunction, showing impaired oxidative phosphorylation and FOXO1 nuclear localization in response to Metformin.

bioRxiv · Oct 1, 2025 · PreprintDevelopmental Biology