Evolution-guided engineering of small-molecule biosensors
Tim Snoek, Evan Kirk Chaberski, Francesca Ambri, Stefan Kol, Sara Petersen Bjørn, Bo Pang, Jesus F. Barajas, Ditte Hededam Welner, Michael Krogh Jensen, Jay D. Keasling
This paper describes a method to evolve and functionalize biosensors in yeast by optimizing ligand specificity and transfer functions through directed evolution.
Nucleic Acids Research · Oct 24, 2019Peer-reviewedSynthetic Biology