Author

Francesca Ambri

Novo Nordisk FoundationORCID 0000-0002-1999-9294Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:yeast· 4 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1

Frequent Co-Authors

Jay D. KeaslingiD· 4 shared Michael Krogh JenseniD· 4 shared Suresh SudarsaniD· 2 shared Tim SnoekiD· 2 shared Alex A. Javanpour· 1 shared Bo PangiD· 1 shared Chang C. LiuiD· 1 shared David Romero-SuáreziD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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4 shared papersSynthetic Biology

Jay D. KeaslingORCID

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4 papers

Recent·Most cited

Integrating continuous hypermutation with high-throughput screening for optimization of cis,cis-muconic acid production in yeast

Emil D. Jensen, Francesca Ambri, Marie B. Bendtsen, Alex A. Javanpour, Chang C. Liu, Michael Krogh Jensen, Jay D. Keasling

The paper develops a directed evolution workflow combining OrthoRep and a transcription factor-based biosensor to optimize cis,cis-muconic acid production in yeast, achieving >13-fold higher titers.

Microbial Biotechnology · Mar 1, 2021Peer-reviewedSynthetic Biology

Regulatory control circuits for stabilizing long-term anabolic product formation in yeast

Vasil D’Ambrosio, Eleonora Dore, Roberto Di Blasi, Marcel A. van den Broek, Suresh Sudarsan, Jolanda ter Horst, Francesca Ambri, Morten Otto Alexander Sommer, Peter Rugbjerg, Jay D. Keasling, Robert Mans, Michael Krogh Jensen

The paper designs synthetic control circuits in yeast to stabilize vanillin-β-glucoside production over multiple generations, achieving higher yields in fermentation.

Metabolic Engineering · Jul 24, 2020Peer-reviewedSynthetic Biology

Evolution-guided engineering of small-molecule biosensors

Tim Snoek, Evan Kirk Chaberski, Francesca Ambri, Stefan Kol, Sara Petersen Bjørn, Bo Pang, Jesus F. Barajas, Ditte Hededam Welner, Michael Krogh Jensen, Jay D. Keasling

This paper describes a method to evolve and functionalize biosensors in yeast by optimizing ligand specificity and transfer functions through directed evolution.

Nucleic Acids Research · Oct 24, 2019Peer-reviewedSynthetic Biology

An orthogonal and pH-tunable sensor-selector for muconic acid biosynthesis in yeast

Tim Snoek, David Romero-Suárez, Jie Zhang, Francesca Ambri, Mette L. Skjoedt, Suresh Sudarsan, Michael Krogh Jensen, Jay D. Keasling

The paper develops a synthetic selection system in yeast to enrich for high-producing muconic acid variants by coupling production to cell fitness through a pH-tunable sensor-selector.

ACS Synthetic Biology · Apr 3, 2018Peer-reviewedSynthetic Biology