The Coronavirus Envelope Is Modulated by Host Inflammation and Enriched in Bioactive Lipids Required for Replication
Victoria J. Tyrrell, Ανδρέας Ζαραγκούλιας, Wendy Powell, Miran Elfar, Valeria C. Grossoni, Federica Monaco, Majd B. Protty, Ewen Stenhouse, James Heyman, Daniela Sofia Albino Costa, Lisa M. Roche, Ceri-Ann Brigid Lynch, Peter Ghazal, Simon A. Jones, Gerard J. Lambeau, , Valerie B. O’Donnell
This study characterizes the lipid composition of SARS-CoV-2 envelopes from cultured strains and patient isolates, showing inflammation-induced changes and identifying lipid targets for antiviral and antithrombotic strategies.
bioRxiv · Nov 3, 2025 · PreprintImmunology