I. R. Henderson

Discrete and conserved inflammatory signatures drive thrombosis in different organs after Salmonella infection

This study identifies discrete inflammatory signatures driving thrombosis in the spleen and liver after Salmonella infection, revealing both organ-specific and shared mechanisms.

Different vaccine platforms result in distinct antibody responses to the same antigen in haemodialysis patients

This study compares antibody responses in haemodialysis patients after vaccination with different platforms, finding mRNA vaccines induce better functional responses than viral vectors.

Inhibition of Neisseria gonorrhoeae complement-mediated killing during acute gonorrhoea is dependent upon the IgG2:IgG3 antibody ratio

The paper identifies that a high IgG2:IgG3 antibody ratio inhibits complement-mediated killing of Neisseria gonorrhoeae, revealing a mechanism for bacterial resistance.

Genome-wide synthetic-lethality screen of Bam complex associated genes in Escherichia coli

The paper identifies synthetic-lethal interactions of Bam complex associated genes in E. coli, revealing dependencies on lipid composition and peptidoglycan synthesis.

Transposon mutagenesis screen in Klebsiella pneumoniae identifies genetic determinants required for growth in human urine and serum

This study identifies essential genes for Klebsiella pneumoniae growth in human urine and serum using transposon mutagenesis, highlighting potential antimicrobial targets.

Salmonella infection induces the reorganisation of follicular dendritic cell networks concomitant with the failure to generate germinal centres

This study shows that Salmonella infection disrupts follicular dendritic cell networks and prevents germinal center formation in the spleen.

Vi polysaccharide and conjugated vaccines afford similar early, IgM or IgG-independent control of infection but boosting with conjugated Vi vaccines sustains the efficacy of immune responses

This study compares the efficacy of Vi polysaccharide and conjugated Vi vaccines in protecting against Salmonella Typhi, finding that conjugated vaccines sustain immune responses better over time.

Machine learning reveals conserved chromatin patterns determining meiotic recombination sites in plants

The paper uses machine learning to identify key chromatin features that determine meiotic recombination sites in plants, finding that three features can predict crossover sites with 90% accuracy.

HEAT SHOCK FACTOR BINDING PROTEIN limits meiotic crossovers by repressing HEI10 transcription

This study identifies HSBP as a repressor of HEI10 transcription and meiotic crossovers in Arabidopsis by binding to HSFs and maintaining DNA methylation at the HEI10 promoter.

DpaA detaches Braun's lipoprotein from peptidoglycan

This study identifies DpaA as an amidase that detaches Braun's lipoprotein from peptidoglycan in E. coli, revealing dynamic regulation of the cell envelope under stress.

YhcB coordinates peptidoglycan and LPS biogenesis with phospholipid synthesis during Escherichia coli cell growth.

This study identifies YhcB as a coordinator of peptidoglycan, LPS, and phospholipid synthesis in E. coli, revealing its role in envelope stability and cell size control.

CRISPR targeting of MEIOTIC-TOPOISOMERASE VIB-dCas9 to a recombination hotspot is insufficient to increase crossover frequency in Arabidopsis

This study attempts to increase crossover frequency in Arabidopsis by targeting a recombination hotspot with CRISPR-dCas9-MTOPVIB but finds no significant change in crossover frequency or pattern.

Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

The paper identifies a new bacterial secretion system, Aat, that acylates a lipoprotein, CexE, on a glycine residue instead of the typical cysteine, leading to surface display of the protein.

BamA and BamD are essential for the secretion of trimeric autotransporter adhesins

This study shows that BamA and BamD are essential for secreting trimeric autotransporters, while BamB, C, E, TamA, and TamB are not required for this process.

Structure-function characterization of the conserved regulatory mechanism of the Escherichia coli M48 metalloprotease BepA

The paper presents the crystal structure of E. coli BepA, an M48 metalloprotease, and shows that its active site plug regulates function and is conserved across the family.

Iron is a ligand of SecA-like metal-binding domains in vivo

This study identifies iron as a ligand for SecA-like metal-binding domains in E. coli, showing that these domains bind iron preferentially and that azide disrupts this interaction.

DeepTetrad: high-throughput analysis of meiotic tetrads by deep learning in plants

DeepTetrad uses deep learning to analyze pollen tetrads and measure crossover frequency and interference in Arabidopsis plants.