MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments
Y. Contreras-Baeza, P. Y. Sandoval, R. Alarcon, A. Galaz, F. Cortes-Molina, K. Alegria, F. Baeza-Lehnert, R. Arce-Molina, A. Guequen, C. A. Flores, A. A. San Martin, L. F. Barros
The paper revises the kinetic properties of MCT4, showing it has high lactate affinity and can extrude lactate in high-lactate environments, challenging previous pH probe-based estimates.
bioRxiv · Mar 27, 2019 · PreprintPhysiology