Author

L. F. Barros

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Assay:fluorescence / live-cell microscopy· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Research Focus:imputation· 1

Frequent Co-Authors

A. Galaz· 3 shared P. Y. Sandoval· 3 shared A. San Martin· 2 shared F. Cortes-Molina· 2 shared K. Alegria· 2 shared R. Arce-Molina· 2 shared S. Schirmeier· 2 shared A. A. San Martin· 1 shared

Activity by Year

2019-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersCell Biology

A. Galaz

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Highly responsive single-fluorophoreindicator to explore lactate dynamics in high calcium environments

A. Galaz, P. Y. Sandoval, I. Soto, H. Hertenstein, J. Schweizer, S. Schirmeier, L. F. Barros, A. San Martin

The paper develops a single-fluorophore lactate indicator, CanlonicSF, suitable for high Ca2+ environments, showing improved sensitivity and specificity over existing FRET-based indicators.

bioRxiv · Oct 1, 2020 · PreprintCell Biology

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

R. Arce-Molina, F. Cortes-Molina, P. Y. Sandoval, A. Galaz, K. Alegria, S. Schirmeier, L. F. Barros, A. San Martin

The paper introduces PyronicSF, a GFP-based sensor for real-time mitochondrial pyruvate transport, concentration, and flux, revealing the MPC's role in regulating respiration vs. anaplerosis/gluconeogenesis.

bioRxiv · Apr 17, 2019Cell Biology

MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments

Y. Contreras-Baeza, P. Y. Sandoval, R. Alarcon, A. Galaz, F. Cortes-Molina, K. Alegria, F. Baeza-Lehnert, R. Arce-Molina, A. Guequen, C. A. Flores, A. A. San Martin, L. F. Barros

The paper revises the kinetic properties of MCT4, showing it has high lactate affinity and can extrude lactate in high-lactate environments, challenging previous pH probe-based estimates.

bioRxiv · Mar 27, 2019 · PreprintPhysiology