Author

K. Alegria

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1 Organism:Drosophila· 1 Assay:fluorescence / live-cell microscopy· 1

Frequent Co-Authors

A. A. San Martin· 2 shared A. Galaz· 2 shared F. Cortes-Molina· 2 shared L. F. Barros· 2 shared P. Y. Sandoval· 2 shared R. Arce-Molina· 2 shared A. Guequen· 1 shared A. San Martin· 1 shared

Activity by Year

2019-2019 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

A. A. San Martin

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

A highly responsive pyruvate sensor reveals pathway-regulatory role of the mitochondrial pyruvate carrier MPC

R. Arce-Molina, F. Cortes-Molina, P. Y. Sandoval, A. Galaz, K. Alegria, S. Schirmeier, L. F. Barros, A. San Martin

The paper introduces PyronicSF, a GFP-based sensor for real-time mitochondrial pyruvate transport, concentration, and flux, revealing the MPC's role in regulating respiration vs. anaplerosis/gluconeogenesis.

bioRxiv · Apr 17, 2019Cell Biology

MCT4 is a high affinity transporter capable of exporting lactate in high-lactate environments

Y. Contreras-Baeza, P. Y. Sandoval, R. Alarcon, A. Galaz, F. Cortes-Molina, K. Alegria, F. Baeza-Lehnert, R. Arce-Molina, A. Guequen, C. A. Flores, A. A. San Martin, L. F. Barros

The paper revises the kinetic properties of MCT4, showing it has high lactate affinity and can extrude lactate in high-lactate environments, challenging previous pH probe-based estimates.

bioRxiv · Mar 27, 2019 · PreprintPhysiology

MitoToxy Assay: a novel cell-based method for the assessment of metabolic toxicity in a multiwell plate format using a lactate FRET nanosensor, Laconic

Y. Contreras, S. Ceballo, R. Arce, P. Sandoval, K. Alegria, F. Barros, A. A. San Martin

The paper introduces a cell-based assay using a lactate FRET nanosensor to detect mitochondrial toxicity in drug development with high sensitivity and throughput.

bioRxiv · Mar 20, 2019Pharmacology & Toxicology