Author

N. Pinotsis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:structural biology· 2 Approach:comparative / phylogenetic analysis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

F. G. Kozielski· 2 shared M. W. Bowler· 2 shared S. Ma· 2 shared A. Krüger· 1 shared B. H. Hahn· 1 shared C. Dickson· 1 shared C. Litz· 1 shared C. Monit· 1 shared

Activity by Year

2022-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersBiochemistry

F. G. Kozielski

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

High-confidence placement of difficult-to-fit fragments into electron density by using anomalous signals - a case study using hits targeting SARS-CoV-2 non-structural protein 1

F. G. Kozielski, S. Ma, M. W. Bowler, V. Mykhaylyk, N. Pinotsis

This paper demonstrates a method to identify multiple binding orientations of small molecule fragments using anomalous signals from sulphur and chlorine atoms, applied to SARS-CoV-2 nsp1 fragments.

bioRxiv · Jun 16, 2023 · PreprintBiochemistry

Two ligand-binding sites on SARS-CoV-2 non-structural protein 1 revealed by fragment-based x-ray screening

S. Ma, S. Damfo, J. Lou, N. Pinotsis, M. W. Bowler, S. Haider, F. G. Kozielski

This study identifies two ligand-binding sites on SARS-CoV-2 nsp1 using X-ray crystallography and fragment-based screening, offering a foundation for inhibitor development.

bioRxiv · Jun 12, 2022Biochemistry

Discovery of a non-canonical prototype long-chain monoacylglycerol lipase through a structure-based endogenous reaction intermediate complex

N. Pinotsis, A. Krüger, N. Tomas, S. D. Chatziefthymiou, C. Litz, S. A. Mortensen, M. Daffe, H. Marrakchi, G. Antranikian, M. Wilmanns

The paper identifies and characterizes a non-canonical long-chain monoacylglycerol lipase using a high-resolution structure of an enzyme-substrate complex.

bioRxiv · Apr 7, 2022Biochemistry

Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV

L. Zuliani-Alvarez, M. Larsen, J. Rasaiyaah, C. Monit, S. O. Perry, R. Sumner, S. McAlpine-Scott, C. Dickson, K. M. Rifat Faysal, L. Hilditch, R. Miles, F. Bibollet-Ruche, B. H. Hahn, T. Bocking, N. Pinotsis, , G. J. Towers

The paper compares pandemic HIV-1(M) and non-pandemic HIV strains, finding that non-pandemic strains activate cGAS and TRIM5 in myeloid cells, leading to antiviral responses and poor replication.

bioRxiv · Jan 21, 2022 · PreprintImmunology