Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma
J. G. M. Strijker, G. Pascual-Pasto, Y. J. Kalmeijer, E. Kalaitsidou, C. Zhao, B. McIntyre, S. Matlaga, L. L. Visser, M. Barisa, C. Himsworth, R. Shah, H. Muller, L. G. Schild, P. G. Hains, Q. Zhong, , J. Wienke
This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.
bioRxiv · Apr 5, 2024Cancer Biology