Author

J. Wienke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Research Focus:drug response / drug discovery· 3 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. Anderson· 3 shared M. Barisa· 3 shared B. B. van Rijn· 2 shared C. Himsworth· 2 shared F. van den Ham· 2 shared F. van Wijk· 2 shared H. Muller· 2 shared J. G. M. Strijker· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersCancer Biology

J. Anderson

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

J. G. M. Strijker, G. Pascual-Pasto, Y. J. Kalmeijer, E. Kalaitsidou, C. Zhao, B. McIntyre, S. Matlaga, L. L. Visser, M. Barisa, C. Himsworth, R. Shah, H. Muller, L. G. Schild, P. G. Hains, Q. Zhong, , J. Wienke

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

bioRxiv · Apr 5, 2024Cancer Biology

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

M. Barisa, E. Zappa, H. Muller, R. Shah, J. Buhl, B. Draper, C. Himsworth, C. Bowers, S. Munnings-Tomes, M. Nicolaidou, S. Morlando, K. Birley, C. Leboreiro-Babe, A. Vitali, L. Privitera, , J. Anderson

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

bioRxiv · Feb 19, 2024Bioengineering

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

J. Wienke, L. L. Visser, W. M. Kholosy, K. M. Keller, M. Barisa, S. Munnings-Tomes, E. Carlton, E. Poon, A. Rodriguez, R. Bernardi, F. Van den Ham, S. R. Van Hooff, Y. A. H. Matser, M. Tas, K. P. S. Langenberg, , J. J Molenaar

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

bioRxiv · Jul 15, 2022Cancer Biology

Human placental bed transcriptomic profiling reveals inflammatory activation of endothelial cells in preeclampsia

L. Brouwers, J. Wienke, M. Mokry, P. G. Nikkels, T. E. Vogelvang, A. Franx, F. van Wijk, B. B. van Rijn

The paper identifies inflammatory activation of endothelial cells in preeclampsia through transcriptomic profiling and systemic biomarker analysis.

bioRxiv · Oct 18, 2021 · PreprintImmunology

Human regulatory T cells at the maternal-fetal interface show functional site-specific adaptation with tumor-infiltrating-like features

J. Wienke, L. Brouwers, L. M. van der Burg, M. Mokry, R. C. Scholman, P. G. Nikkels, B. B. van Rijn, F. van Wijk

This study identifies a distinct transcriptional profile of uterine regulatory T cells at the maternal-fetal interface, showing features similar to tumor-infiltrating Tregs.

bioRxiv · Nov 5, 2019Immunology