Q. Zhong

HomoeoGWAS enables experiment-wide homoeolog-group interaction mapping in allopolyploid crops

HomoeoGWAS identifies homoeolog-group interactions in allopolyploid crops by analyzing genotype encodings and controlling family-wise error across multiple species.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

Comparison and Evaluation of Neutralization of Clinically Frequently Used Antimicrobial Agents Using Three Different Culture Media in Simulated Blood Cultures

This study evaluates three blood culture media for antimicrobial neutralization, finding BACT/ALERT media outperformed others in recovery rates, while Thermo media had the lowest performance.

Inhalable point-of-care urinary diagnostic platform

This paper introduces a point-of-care diagnostic platform for lung cancer using inhalable nanosensors that detect tumor-associated proteases through urine analysis.

Self-assembly vascularized human cardiac organoids model cardiac diseases in petri dishes and in mice

This study generates self-assembling cardiac organoids from human pluripotent stem cells to model myocardial infarction and SARS-CoV-2 fibrosis, showing in vitro and in vivo disease characteristics and vascular integration.

Re-engineering of TNFα-NF-κB signalling dynamics in cancer cells using pathogenic E. coli effectors

This study uses bacterial effectors to manipulate NF-κB signalling in cancer cells, showing that combining Tir, NleE, and TNF can eliminate 95% of pancreatic cancer cells with minimal NF-κB activation.

Proteomic-based stratification of intermediate-risk prostate cancer patients

The paper identifies an 18-protein signature from proteomic data to stratify intermediate-risk prostate cancer patients into low- and high-risk groups for biochemical recurrence.

Pressure-driven membrane inflation through nanopores on the cell wall

The paper studies how osmotic pressure through nanopores affects membrane deformation in walled cells, finding a critical pore size that determines whether the membrane inflates or remains intact.

Reactive myelopoiesis and FX-expressing monocyte-derived macrophages triggered by chemotherapy promote cancer lung metastasis

This study shows chemotherapy-induced reactive myelopoiesis and FX-expressing macrophages promote cancer lung metastasis through CCL2/CCR2 axis and coagulation-inflammation interplay.

Multiscale profiling of enzyme activity in cancer

This paper develops methods to measure enzyme activity in cancer across multiple scales, revealing protease dysregulation and dynamic interactions between tumor cells and their microenvironment.

The glycosphingolipid inhibitor eliglustat inhibits autophagy in osteoclasts to increase bone mass and reduce myeloma bone disease

Eliglustat inhibits autophagy in osteoclasts, reducing MM bone disease and suggesting its use as a treatment for bone loss disorders.

Activatable zymography probes enable in situ localization of protease dysregulation in cancer

This paper introduces activatable zymography probes (AZPs) to detect protease activity in cancer tissues, demonstrating their utility in classifying disease and guiding therapeutic design.

High-throughput proteomic analysis of FFPE tissue samples facilitates tumor stratification

This study develops a proteomic workflow for FFPE tissues to stratify prostate cancer and DLBCL samples, identifying MPO as a prognostic marker and showing FFPE's utility for biomarker discovery.

Polymeric perfluorocarbon nanoemulsions are ultrasound-activated wireless drug infusion catheters

This paper develops polymeric perfluorocarbon nanoemulsions as ultrasound-activated drug delivery systems, demonstrating their ability to deliver a wide range of drugs noninvasively and effectively in vivo.

Cyclic-di-adenosine monophosphate (c-di-AMP) is required for osmotic regulation in Staphylococcus aureus but dispensable for viability in anaerobic conditions

This study identifies c-di-AMP's role in osmotic regulation in S. aureus but shows it is not required for anaerobic growth.