J. Anderson

Comprehensive multi-site profiling of the malignant pleural mesothelioma micro-environment identifies candidate molecular determinants of histopathologic type

This study uses single-cell RNA-sequencing and other omics data to analyze the molecular features of pleural mesothelioma subtypes and identify potential drivers of tumor cell states.

Blocking MIF secretion enhances CAR T-cell efficacy against neuroblastoma

This study identifies MIF as a key immunosuppressive factor in neuroblastoma that inhibits CAR T-cell efficacy, showing that blocking MIF enhances T-cell activation and therapeutic potential.

Quantitative Superresolution Imaging of F-Actin in the Cell Body and Cytoskeletal Protrusions Using Phalloidin-Based Single-Molecule Labeling and Localization Microscopy

This paper introduces phalloidin-based single-molecule labeling and localization microscopy (SMLLM) for superresolution imaging of F-actin, showing improved quantification and structural preservation in dendritic cells.

Functional avidity of anti-B7H3 CAR-T constructs predicts antigen density thresholds for triggering effector function

The paper evaluates how the functional avidity of anti-B7H3 CAR-T constructs relates to their ability to trigger effector function against tumors with varying antigen density.

Preservation of memory B cell homeostasis in an individual producing broadly neutralising antibodies against HIV-1

The paper isolates a broadly neutralizing HIV-1 antibody from an untreated HIV-1 patient and shows memory B cells remain functional despite viral infection.

A high-cholesterol zebrafish diet promotes hypercholesterolemia and fasting-associated liver triglycerides accumulation

This study shows that a high-cholesterol diet in zebrafish leads to hypercholesterolemia and fasting-induced liver triglyceride accumulation, with lipid accumulation in adipocytes contributing to hepatic steatosis.

A generalizable epigenetic clock captures aging in two nonhuman primates.

This paper develops an epigenetic clock for rhesus macaques using DNA methylation data, achieving high accuracy in predicting age across different populations and species.

OPS-γδ: allogeneic opsonin-secreting γδT cell immunotherapy for solid tumours mediates direct and bystander immunity

OPS-γδ cells, engineered to secrete opsonins and stabilized IL15, show enhanced cytotoxicity and bystander activation for solid tumor control.

Productive and latent HIV infections originate in resting CD4+ T cells

This study shows that resting CD4+ T cells are the initial source of both productive and latent HIV infections in the earliest stages of detectable infection.

The Defenders of the Alveolus Succumb in COVID-19 Pneumonia to SARS-CoV-2, Necroptosis, Pyroptosis and Panoptosis

This paper investigates how SARS-CoV-2 infection leads to the destruction of alveolar type II cells in fatal COVID-19 pneumonia through multiple inflammatory cell death pathways and suggests potential therapeutic strategies.

Integrative analysis of neuroblastoma by single-cell RNA sequencing identifies the NECTIN2-TIGIT axis as a target for immunotherapy

The paper uses single-cell RNA sequencing to analyze neuroblastoma and identifies the NECTIN2-TIGIT axis as a potential target for immunotherapy.

Detecting sources of immune activation and viral rebound in HIV infection

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

Facultative winter accession of Camelina sativa (L. Crantz) with early maturity contributes to understanding of the role of FLOWERING LOCUS C in camelina flowering

The paper identifies a facultative winter camelina accession with a subfunctional FLC allele that flowers earlier than a common winter accession, aiding marker-assisted breeding and cytotype classification.

Gene loss during a transition to multicellularity

The paper examines gene loss in volvocine algae during multicellular evolution, finding that gene loss drives developmental complexity through novel protein interactions and network reconfiguration.

Climate change alters plant-herbivore interactions

This study examines how climate change factors like temperature, CO2, and drought affect plant-herbivore interactions, finding increased herbivory and altered development rates.

Selection favors adaptive plasticity in a long-term reciprocal transplant experiment

The paper tests whether phenotypic plasticity is adaptive in a plant species under source-sink dynamics, finding stabilizing selection on plasticity in specific leaf area and stomatal density.

Tumor to normal single cell mRNA comparisons reveal a pan-neuroblastoma cancer cell

The paper compares tumor and normal single-cell mRNA data to show neuroblastoma cells resemble fetal sympathoblasts across diverse samples.

WEGE: A NEW METRIC FOR RANKING LOCATIONS FOR BIODIVERSITY CONSERVATION

The paper develops and validates the WEGE index to rank biodiversity importance of sites based on species endemism and threat status, outperforming existing metrics for conservation prioritization.

Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy

This study shows that FGFR1 promotes T-DM1 resistance and tumor recurrence in HER2+ breast cancer, suggesting FGFR inhibitors like FIIN4 could be combined with T-DM1 for better treatment.

Voltage-dependent K+ Channels Improve the Energy Efficiency of Signalling in Blowfly Photoreceptors

The paper models blowfly photoreceptors to show voltage-dependent K+ channels improve energy efficiency in analogue coding by adjusting membrane resistance and bandwidth based on light conditions.