Author

V. Guryev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 3 Bioengineering· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

D. C. J. Spierings· 3 shared M. A. T. M. van Vugt· 2 shared P. M. Lansdorp· 2 shared A. Aboobaker· 1 shared A. Audrey· 1 shared A. de Bruin· 1 shared A. M. Heijink· 1 shared A. M. Szasz· 1 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersCell Biology

D. C. J. Spierings

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Author profile →

8 papers

Recent·Most cited

Cellular Senescence Affects ECM Regulation in COPD Lung Tissue

R. R. Woldhuis, N. J. Bekker, J. L. L. Nijnatten, M. Banchero, W. Kooistra, K. J. C. Wolters, P. L. Horvatovich, V. Guryev, M. van den Berge, W. Timens, C.-A. Brandsma

This study identifies ECM gene and protein changes in COPD lung tissue linked to cellular senescence, confirming in vivo associations previously observed in vitro.

bioRxiv · Aug 2, 2023 · PreprintPathology

Sister chromatid exchanges induced by perturbed replication are formed independently of homologous recombination factors

A. M. Heijink, C. Stok, D. Porubsky, E. M. Manolika, Y. P. Kok, M. Everts, H. R. de Boer, A. Audrey, E. Wierenga, V. Guryev, D. C. J. Spierings, P. Knipscheer, A. Ray Chaudhuri, P. M. Lansdorp, M. A. T. M. van Vugt

This study shows PARP inhibitors induce sister chromatid exchanges (SCEs) through under-replicated DNA processed in mitosis, independent of homologous recombination factors.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Inversion of asymmetric histone deposition upon replication stress

F. J. Dekker, M. Zwinderman, T. Jessurun Lobo, P. Van der Wouden, D. C. J. Spierings, M. A. T. M. van Vugt, P. Lansdorp, V. Guryev

The paper investigates how replication stress alters histone deposition asymmetry on sister chromatids, showing a shift from lagging to leading strand bias.

bioRxiv · Apr 20, 2021 · PreprintCell Biology

Proteogenomics Reveals how Metastatic Melanoma Modulates the Immune System to Allow Immune Evasion

J. Gil, Y. Kim, B. Szeitz, V. Doma, U. Cakır, N. Pinto de Almeida, Y. Paco Hagemeijer, V. Guryev, J. G. Johansson, Y. Sharma, I. Pla Parada, Z. Horvath, J. de Siqueira Guedes, G. Monnerat, F. C. Nogueira, , G. Marko-Varga

This paper analyzes proteogenomic data from melanoma patients to show how metastatic melanoma alters metabolism and immune responses to evade immune detection.

bioRxiv · Apr 10, 2021 · PreprintCancer Biology

The developmental stage of the medulloblastoma cell-of-origin restricts Hedgehog pathway usage and drug sensitivity

M. J. Smit, I. Armandari, I. Bockaj, T. E. I. Martini, W. W. Zomerman, Z. Siragna, T. G. J. Meeuwsen-de Boer, F. J. G. Scherpen, M. H. Schoots, M. Ritsema, W. F. A. den Dunnen, E. H. Hoving, J. T. M. L. Paridaen, G. de Haan, V. Guryev, S. Bruggeman

The paper shows that the developmental stage of medulloblastoma cell-of-origin affects Hedgehog pathway usage and drug sensitivity, with downstream pathway targets being more effective in infant patients.

bioRxiv · Jan 22, 2021Cancer Biology

Reduced expression of C/EBPβ-LIP extends health- and lifespan in mice

C. Müller, L. M. Zidek, T. Ackermann, T. de Jong, P. Liu, V. Kliche, M. A. Zaini, G. Kortman, L. Harkema, D. S. Verbeek, J. P. Tuckermann, J. von Maltzahn, A. de Bruin, Z.-Q. Wang, V. Guryev, C. F. Calkhoven

This study shows that reducing C/EBPβ-LIP expression in mice delays age-related phenotypes and extends lifespan, suggesting therapeutic potential for age-related diseases.

bioRxiv · Jan 18, 2018Cell Biology

BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes

N. van Wietmarschen, S. Merzouk, N. Halsema, D. C. J. Spierings, V. Guryev, P. M. Lansdorp

This study shows that BLM helicase suppresses recombination at G-quadruplex motifs in transcribed genes, preventing genomic instability in human and murine cells.

bioRxiv · Aug 7, 2017Cell Biology

A platform for efficient transgenesis in Macrostomum lignano, a flatworm model organism for stem cell research

J. Wudarski, D. Simanov, K. Ustyantsev, K. de Mulder, M. Grelling, M. Grudniewska, F. Beltman, L. Glazenburg, T. Demircan, J. Wunderer, W. Qi, D. B. Vizoso, P. M. Weissert, D. Olivieri, S. Mouton, , E. Berezikov

This paper develops a transgenesis method for Macrostomum lignano and annotates its genome to enable genetic studies on stem cells and regeneration.

bioRxiv · Jun 18, 2017Bioengineering