Author

F. J. Sedlazeck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1 Genetic & Genomic Medicine· 1 Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

A. A. Abdulkadir· 1 shared A. Carroll· 1 shared A. English· 1 shared A. Kolesnikov· 1 shared A. Munoz-Barrera· 1 shared A. Rajan· 1 shared A. Rhie· 1 shared All of Us Research Program Long Read Working Group· 1 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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1 shared paperGenomics

A. A. Abdulkadir

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Author profile →

5 papers

Recent·Most cited

Evolution-guided association mapping using long-read genomes from a self-identified Black or African American cohort in All of Us

N. Soisangwan, K. V. Garimella, M. C. Schatz, E. E. Eichler, F. J. Sedlazeck, M. E. Talkowski, F. Cunial, S. K. Lee, All of Us Research Program Long Read Working Group, PingHsun Hsieh

This study uses long-read genomes from a Black or African American cohort to identify genomic regions under recent positive selection and their associations with phenotypes.

medRxiv · Nov 4, 2026 · PreprintGenetic & Genomic Medicine

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

N. D. Olson, N. Dwarshuis, N. F. Hansen, S. Koren, A. Rhie, J. H. McDaniel, J. Wagner, G. Berry, K. Shafin, A. English, C. T. Saunders, R. Kundu, J. M. Holt, D. Freed, A. A. Abdulkadir, , Lan

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

bioRxiv · Oct 1, 2026 · PreprintGenomics

Intratumoral heterogeneity and clonal evolution induced by HPV integration

K. Akagi, D. E. Symer, M. Mahmoud, B. Jiang, S. Goodwin, D. Wangsa, Z. Li, W. Xiao, J. D. Dunn, T. Ried, K. R. Coombes, F. J. Sedlazeck, M. L. Gillison

This study identifies heterocateny as a structural variation caused by HPV integration, promoting intratumoral heterogeneity and clonal evolution in oropharyngeal cancers.

bioRxiv · Aug 11, 2022Cancer Biology

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

H. V. Doddapaneni, S. J. Cregeen, R. Sucgang, Q. Meng, X. Qing, V. Avadhanula, H. Chao, V. Menon, E. Nicholson, D. Henke, F.-A. Piedra, A. Rajan, Z. Momin, K. Kottapalli, K. L. Hoffman, , R. A. Gibbs

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

bioRxiv · Jul 27, 2020 · PreprintMicrobiology

Ancestral admixture is the main determinant of global biodiversity in fission yeast

S. Tusso, B. P. S. Nieuwenhuis, F. J. Sedlazeck, J. W. Davey, D. Jeffares, J. B. W. Wolf

This study shows that admixture between two ancestral lineages of fission yeast drives global biodiversity, with phenotypic variation and reproductive compatibility linked to ancestry arrangements.

bioRxiv · Jan 22, 2019Evolutionary Biology