V. Menon

Psychosocial experiences are associated with human brain mitochondrial biology

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

Immune Response following FLASH and Conventional Radiation in Diffuse Midline Glioma (DMG)

This study compares the immune response in diffuse midline glioma after FLASH and conventional radiation using single-cell RNA sequencing and flow cytometry, finding differences in type 1 interferon signaling over time.

Defining the architecture of cerebrospinal fluid cellular communities in neuroinflammatory diseases

This study uses scRNA-seq to define immune cell communities in CSF of MS and other neuroinflammatory diseases, identifying changes in cell types and potential therapeutic targets.

Genotype-Phenotype Correlation of T Cell Subtypes Reveals Senescent and Cytotoxic Genes in Alzheimer's Disease

The paper identifies eQTLs in T cell subsets from AD patients and controls, revealing genes related to senescence, cytotoxicity, and synaptic function.

Unique Microglial Transcriptomic Signature within the Hippocampal Neurogenic Niche

The paper identifies a unique microglial transcriptomic signature in the hippocampal neurogenic niche, showing increased phagocytosis and overlap with disease-associated microglia.

Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states

The paper identifies three tissue states in glioblastoma microenvironments using snRNAseq and spatial transcriptomics, linking them to metabolic pathways and clinical outcomes.

A comprehensive analysis of gene expression changes in a high replicate and open-source dataset of differentiating hiPSC-derived cardiomyocytes

The paper analyzes gene expression changes in hiPSC-derived cardiomyocytes using single-cell RNA-seq, identifying key genes that mark differentiation stages and sources of variation across protocols and cell lines.

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

Cell states beyond transcriptomics: integrating structural organization and gene expression in hiPSC-derived cardiomyocytes

The paper integrates gene expression and sarcomere organization in hiPSC-derived cardiomyocytes to predict subcellular states and reveal correlations between transcript abundance and structural patterns.

Time varying connectivity across the brain changes as a function of nicotine abstinence state

This study examines changes in time-varying brain connectivity during nicotine abstinence and links these changes to clinical symptoms of nicotine withdrawal.

Oxamniquine resistance alleles are widespread in Old World Schistosoma mansoni and predate drug deployment

The paper identifies widespread oxamniquine resistance alleles in Old World Schistosoma mansoni populations, showing they predate drug use and exist as standing genetic variation.