J. Wagner

The Genome In A Bottle HG002 assembly-based variant benchmark set enables comprehensive benchmarking of small and structural variants.

The paper introduces a comprehensive variant benchmark set derived from a high-quality diploid assembly, improving small and structural variant detection across complex genomic regions.

Trophic adaptation of large terrestrial omnivores to global change

This study shows that large terrestrial omnivores, like bears, adjust their trophic positions in response to changes in primary productivity and growing season length.

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing

This study uses retrograde tracing to characterize neuron-tumor networks in glioblastoma and shows that targeting these networks can enhance therapeutic outcomes.

Influence of environmental variables, small-scale fisheries and vessel traffic on the distribution and behavior of bottlenose dolphins in a tropical lagoon.

This study examines how environmental factors, fisheries, and vessel traffic affect bottlenose dolphin distribution and behavior in a tropical lagoon, finding habitat preferences linked to prey availability and functional habitats.

Single-cell morphological tracking of liver cell states to identify small-molecule modulators of liver differentiation

Physiological Profiles of Male and Female CrossFit Athletes

This study establishes physiological profiles of elite CrossFit athletes and identifies anthropometric and cardiorespiratory fitness markers correlated with performance.

INTERPRETABLE MACHINE LEARNING UNVEILS KEY PREDICTORS AND DEFAULT VALUES IN AN EXPANDED DATABASE OF HUMAN IN VITRO DERMAL ABSORPTION STUDIES WITH PESTICIDES

This paper uses interpretable machine learning to identify key predictors and establish default dermal absorption values for pesticides based on in vitro human skin studies.

Group 2 innate lymphoid cells constrain type 3/17 lymphocytes in shared stromal niches to restrict liver fibrosis

The paper investigates the role of IL-5+ lymphocytes and type 3/17 lymphocytes in liver fibrosis, showing their spatial relationship and cross-regulation in fibroblast niches.

Ageing impairs the neuro-vascular interface in the heart

This study shows aging reduces nerve density in the left ventricle and dysregulates neuro-regulatory genes, leading to reduced heart rate variability.

MIF-2/D-DT is an atypical atherogenic chemokine that promotes advanced atherosclerosis and hepatic lipogenesis

This study identifies MIF-2 as an atherogenic chemokine that promotes atherosclerosis and hepatic lipogenesis by acting through CXCR4 and SREBP pathways.

Smallpox vaccination induces a substantial increase in commensal skin bacteria that promote pathology and enhance immunity

This paper shows that smallpox vaccination with VACV increases skin commensal bacteria, which promote tissue damage but also enhance immunity and antibody responses.

Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

The paper identifies LOTUS-domain proteins that promote perinuclear P granule formation in C. elegans using proximity labeling and mass spectrometry.

Mass Cytometric and Transcriptomic Profiling of Epithelial-Mesenchymal Transitions in Human Mammary Cell Lines

The paper profiles EMT transition phenotypes in human mammary cell lines using mass cytometry and transcriptomics to understand phenotypic diversity across time and cell lines.

SARS-CoV-2 infects and induces cytotoxic effects in human cardiomyocytes

This study shows SARS-CoV-2 infects human cardiomyocytes, causing cytotoxicity and apoptosis, and confirms this in cardiac tissue models.

Netrin G1 promotes pancreatic tumorigenesis through cancer associated fibroblastdriven nutritional support and immunosuppression

This study identifies Netrin G1 as a promoter of pancreatic ductal adenocarcinoma tumorigenesis by enhancing cancer-associated fibroblast-driven metabolic support and immunosuppression.

Continuous Evaluation of Ligand Protein Predictions: A Weekly Community Challenge for Drug Docking

CELPP evaluates docking workflows by challenging participants to predict new protein-ligand structures weekly, assessing accuracy to identify strengths and weaknesses in drug docking methods.

Peptidoglycan precursor synthesis along the sidewall of pole-growing mycobacteria

The paper investigates peptidoglycan precursor synthesis in mycobacteria, showing that sidewall synthesis responds to cell wall damage while polar synthesis is linked to elongation.

Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet

This study investigates whether iron overload in mouse models of hereditary hemochromatosis exacerbates diet-induced liver disease, finding no evidence of early fibrosis.

Forgot what you like? Evidence for hippocampal dependence of value-based decisions

The paper shows that hippocampal damage leads to inconsistent value-based decisions, suggesting a role for the medial temporal lobe in preference construction and decision consistency.