J. M. Penninger

Reconstructing bat antiviral immunity using epithelial organoids

This study uses bat epithelial organoids to investigate antiviral immunity differences between bats and humans, revealing unique interferon responses and implications for viral pathogenesis.

An automated microfluidic platform integrating functional vascularized organoids-on-chip

This paper develops a microfluidic platform to create functional vascular networks around organoids, demonstrating perfusion within spheroids and vascular organoids over 15 days.

Tumor sialylation controls effective anti-cancer immunity in breast cancer

This study shows that tumor sialylation suppresses anti-cancer immunity in breast cancer by altering immune cell interactions and checkpoint ligands, and that inhibiting sialylation enhances immune response and therapy effectiveness.

Mast cell-derived BH4 is a critical mediator of postoperative pain

This study identifies mast cell-derived BH4 as a key mediator of postoperative pain, showing that substance P triggers BH4-dependent serotonin release in mast cells, and blocking substance P reduces pain.

Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice.

The paper presents a method for analyzing N-glycome diversity in mice tissues, revealing tissue-specific glycosylation patterns and non-canonical structures.

Neuropeptide Neuromedin B does not alter body weight and glucose homeostasis nor does it act as an insulin-releasing peptide

This study investigates the role of Neuromedin B in body weight, glucose homeostasis, and insulin release using genetic models and metabolic analyses.

Low Density Lipoprotein Receptor-Related Protein 1 (LRP1) as an auxiliary host factor for RNA viruses including SARS-CoV-2

This study identifies LRP1 as a host factor that supports infection by multiple RNA viruses, including SARS-CoV-2, through cholesterol-dependent endocytosis.

Glucose intolerance in aging is mediated by the Gpcpd1-GPC metabolic axis

This study identifies Gpcpd1-GPC metabolic pathway perturbation in aging muscle as a driver of glucose intolerance.

Development of a novel, pan-variant aerosol intervention for COVID-19

This paper reports preclinical development and evaluation of aerosolized soluble recombinant human ACE2 (APN01) as a COVID-19 intervention.

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

This study engineers ACE2 glycosylation to enhance its binding to SARS-CoV-2 Spike protein, resulting in a more potent decoy receptor for COVID-19 treatment.

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

This paper develops a mouse-adapted SARS-CoV-2 strain, maVie16, to model COVID-19 in mice, showing that ACE2 is critical for disease and that blocking TNF/IFNγ reduces immunopathology.

The ubiquitin ligase HOIL-1L regulates immune responses by interacting with linear ubiquitin chains

This study shows that the HOIL-1L NZF domain regulates immune responses by binding linear ubiquitin chains, affecting TNF and LPS-induced inflammation in mice.

Community Evaluation of Glycoproteomics Informatics Solutions Reveals High-Performance Search Strategies of Serum N- and O-Glycopeptide Data

This study evaluates glycoproteomics software performance using human serum datasets, identifies high-performance strategies, and provides recommendations for improved analysis.

Dysregulation in mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

The paper identifies dysregulation in mTOR/HIF-1 signaling in SARS-CoV-2 infected cells through proteo-transcriptomics analysis.

Reduced PABPN1 levels causes cytoskeleton disorganization and aberrant differentiation

This study shows that reduced PABPN1 levels disrupt cytoskeletal organization and impair muscle differentiation, with actin overexpression improving these defects.

Improved Sensitivity in Low-Input Proteomics using Micro-Pillar Array-based Chromatography

The paper benchmarks a micro-pillar array column against a conventional nano-flow HPLC column, showing improved sensitivity and peptide/protein identification in low-input proteomics.