Author

F. Nintzel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Approach:deep learning· 1 Research Focus:protein design· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

F. Hollfelder· 2 shared A.-C. Prowald· 1 shared M. Gantz· 1 shared M. Herger· 1 shared M. Penner· 1 shared O. J. Klein· 1 shared P. Barker· 1 shared P. Dupree· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersBiochemistry

F. Hollfelder

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2 papers

Recent·Most cited

Fluorogenic, sub-single-turnover monitoring of enzymatic reactions involving NAD(P)H provides a generalised platform for directed ultrahigh throughput evolution of biocatalysts in microdroplets

M. Penner, O. J. Klein, M. Gantz, F. Nintzel, A.-C. Prowald, S. Boss, P. Barker, P. Dupree, F. Hollfelder

The paper develops a fluorogenic assay for NAD(P)H detection to enable high-throughput screening of biocatalysts in microdroplets, demonstrating improved sensitivity and applicability for glycosyl hydrolases and IREDs.

bioRxiv · Nov 22, 2023 · PreprintBiochemistry

Ultrahigh throughput evolution of tryptophan synthase in droplets via an aptamer-biosensor

R. Scheele, Y. Weber, F. Nintzel, M. Herger, T. S. Kaminski, F. Hollfelder

This paper develops a DNA aptamer biosensor to enable high-throughput screening of tryptophan synthase variants in droplets, identifying 5-fold improved enzymes.

bioRxiv · Oct 11, 2023 · PreprintBiochemistry