Author

F. S. Gruber

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:drug response / drug discovery· 2 Assay:imaging· 1

Frequent Co-Authors

C. Wilson· 3 shared I. H. Gilbert· 3 shared J. R. Swedlow· 3 shared K. D. Read· 3 shared Z. C. Johnston· 3 shared A. Richardson· 2 shared C. L. Barratt· 2 shared I. Georgiou· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersCell Biology

C. Wilson

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Author profile →

3 papers

Recent·Most cited

Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa

Z. C. Johnston, F. S. Gruber, R. Myles, S. V. Kane, A. Richardson, D. P. Day, C. Wilson, K. D. Read, I. H. Gilbert, S. Martins da Silva, C. L. R. Barratt, J. R. Swedlow

This paper adapts a cell painting assay to human spermatozoa to create an image-based fingerprint for studying compound effects on sperm function and contraceptive discovery.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

Sperm Toolbox - A selection of small molecules to study human spermatozoa

F. S. Gruber, A. Richardson, Z. C. Johnston, R. Myles, N. Norcross, D. Day, I. Georgiou, L. Sesma Sanz, C. Wilson, K. D. Read, S. Martins da Silva, C. L. Barratt, I. H. Gilbert, J. R. Swedlow

The paper establishes a small molecule library for studying human spermatozoa and provides a dataset for comparing compound effects and assays.

bioRxiv · May 2, 2023Pharmacology & Toxicology

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

F. S. Gruber, Z. C. Johnston, N. R. Norcross, I. Georgiou, C. Wilson, K. D. Read, I. H. Gilbert, J. R. Swedlow, S. Martins de Silva, C. L. Barratt

A high-throughput screening platform identified 105 compounds that enhance human sperm motility, including novel targets like GABA signaling and PDE10A inhibitors.

Human Reproduction · Jan 20, 2022Peer-reviewedPhysiology