A. Richardson

Broad-spectrum RNA antiviral inspired by ISG15-/- deficiency

The paper identifies a set of 10 ISGs that confer broad-spectrum antiviral resistance and demonstrates their efficacy in protecting against multiple viruses in vivo.

Non-Necroptotic Roles of MLKL in Diet-Induced Obesity, Liver Pathology, and Insulin Sensitivity: Insights from a High Fat, High Fructose, High Cholesterol Diet Mouse Model

This study investigates MLKL's non-necroptotic roles in diet-induced obesity and liver disease using a HFHFrHC mouse model, finding dose-dependent effects on inflammation and metabolic parameters.

Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa

This paper adapts a cell painting assay to human spermatozoa to create an image-based fingerprint for studying compound effects on sperm function and contraceptive discovery.

Sperm Toolbox - A selection of small molecules to study human spermatozoa

The paper establishes a small molecule library for studying human spermatozoa and provides a dataset for comparing compound effects and assays.

Impact of cannabis use on immune cell populations and the viral reservoir in people with HIV on suppressive antiretroviral therapy.

This study examines how cannabis use affects immune cell populations and the HIV reservoir in HIV-positive individuals on antiretroviral therapy, finding reduced T cell activation and potential reservoir size reduction in some subgroups.

Senolytic Treatment Reduces Cell Senescence and Necroptosis in Sod1 Knockout Mice that is Associated with Reduced Inflammation and Hepatocellular Carcinoma

Deletion of Sod1 in motor neurons exacerbates age-related changes in axons and NMJs associated with premature muscle atrophy in aging mice

This study shows that deleting Sod1 in motor neurons worsens age-related muscle atrophy and NMJ changes in old mice, but not in younger mice.

Efficient, selectable marker free gene targeting in soybean using novel Ochrobactrum haywardense-mediated delivery

This paper develops a selectable marker-free gene targeting system in soybean using Ochrobactrum haywardense-mediated delivery, achieving 3.4% targeted insertion and 90% mutation rate in T0 plants.

Boundary domain genes were recruited to suppress bract growth and promote branching in maize

The paper identifies boundary domain genes tsh1 and lg2 that suppress inflorescence leaf growth and promote branching in maize through regulatory networks and gene duplication events.

Necroptosis contributes to chronic inflammation and fibrosis in aging liver

This study shows that necroptosis increases with age in the liver, contributing to chronic inflammation and fibrosis.

Rapid Identification of Neutralizing Antibodies against SARS-CoV-2 Variants by mRNA Display

This study uses mRNA display to identify and engineer neutralizing antibodies against SARS-CoV-2 variants, revealing binding modes and demonstrating their effectiveness against mutations in the spike protein.

Drug repurposing based on a Quantum-Inspired method versus classical fingerprinting uncovers potential antivirals against SARS-CoV-2 including vitamin B12

This paper compares a quantum-inspired method and traditional fingerprinting to repurpose drugs against SARS-CoV-2, identifying vitamin B12 and BMS-986094 as potential antivirals effective against multiple variants.

An ecological niche model to predict the geographic distribution of Haemagogus janthinomys, Dyar, 1921 the yellow fever and Mayaro virus vector, in South America

The hyperlipidaemic drug fenofibrate significantly reduces infection by SARS-CoV-2 in cell culture models

This study shows fenofibrate and its metabolite fenofibric acid reduce SARS-CoV-2 infection in cell culture by up to 70% at clinically achievable concentrations.

Role of necroptosis in chronic hepatic inflammation and liver disease in Cu/Zn superoxide dismutase deficient mice

This study shows that necroptosis contributes to liver inflammation, fibrosis, and HCC progression in Sod1KO mice by increasing pro-inflammatory markers and STAT3 activation.

A heat-shock inducible system for flexible gene expression in cereals

This paper develops a heat-shock inducible gene expression system for cereals, enabling controlled gene activation in barley and wheat without chemical inducers.

The Hoja loca1 Mutant and AUX/IAA Function in Phytomer Development

This study identifies a dominant AUX/IAA mutant in maize, Hoja loca1, which affects aerial organ initiation and leaf patterning but not phytomer initiation, highlighting auxin signaling's role in plant development.

Use of high-refractive index hydrogels and tissue clearing for large biological sample imaging

This study develops high-refractive index hydrogels for stabilizing large biological samples during imaging, enabling effective tissue clearing and light sheet fluorescence microscopy.

Development of humanized mouse and rat models with full-thickness human skin and autologous immune cells

This paper develops humanized mouse and rat models with full-thickness human skin and autologous immune cells to study human host-skin pathogen interactions.

MICRORNA-184 AND ITS LNCRNA SPONGE UCA1 ARE INDUCED IN WOUNDED KERATINOCYTES IN A STORE-OPERATED CALCIUM ENTRY-DEPENDENT MANNER

This study shows that miR-184 and its sponge UCA1 are induced in wounded keratinocytes via SOCE, supporting migration and potentially regulating miR-184 activity.