Author

I. Georgiou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. L. Barratt· 2 shared C. Wilson· 2 shared F. S. Gruber· 2 shared I. H. Gilbert· 2 shared J. R. Swedlow· 2 shared K. D. Read· 2 shared Z. C. Johnston· 2 shared A. Antanaviciute· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersPharmacology & Toxicology

C. L. Barratt

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Sperm Toolbox - A selection of small molecules to study human spermatozoa

F. S. Gruber, A. Richardson, Z. C. Johnston, R. Myles, N. Norcross, D. Day, I. Georgiou, L. Sesma Sanz, C. Wilson, K. D. Read, S. Martins da Silva, C. L. Barratt, I. H. Gilbert, J. R. Swedlow

The paper establishes a small molecule library for studying human spermatozoa and provides a dataset for comparing compound effects and assays.

bioRxiv · May 2, 2023Pharmacology & Toxicology

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.

A. Czarna, J. Plewka, L. Kresik, A. Matsuda, A. Karim, C. Robinson, S. O Byrne, F. Cunningham, I. Georgiou, M. Pachota, G. Popowicz, P. G. Wyatt, G. Dubin, K. Pyrc

The paper presents the crystal structure of SARS-CoV-2 nsp14 in apo-form and explains how nsp10 modulates its exonuclease activity through structural changes.

Structure · Aug 1, 2022Peer-reviewedMicrobiology

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

F. S. Gruber, Z. C. Johnston, N. R. Norcross, I. Georgiou, C. Wilson, K. D. Read, I. H. Gilbert, J. R. Swedlow, S. Martins de Silva, C. L. Barratt

A high-throughput screening platform identified 105 compounds that enhance human sperm motility, including novel targets like GABA signaling and PDE10A inhibitors.

Human Reproduction · Jan 20, 2022Peer-reviewedPhysiology

Targeting BDCA2 suppresses Plasmacytoid dendritic cell dependent interferon response and tissue fibrosis

R. L. Ross, C. Corinaldesi, G. Migneco, I. Carr, A. Antanaviciute, A. Carriero, C. Wasson, I. Georgiou, J. H. W. Distler, S. Holmes, Y. M. El-Sherbiny, C. S. McKimmie, F. Del Galdo

This study shows that targeting BDCA2 reduces pDC-driven interferon responses and fibrosis in preclinical models of skin inflammation.

bioRxiv · Jan 30, 2020 · PreprintImmunology