Author

J. R. Swedlow

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 1 Biophysics· 1 Pharmacology & Toxicology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:drug response / drug discovery· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:dimensionality reduction· 1

Frequent Co-Authors

C. Wilson· 3 shared F. S. Gruber· 3 shared I. H. Gilbert· 3 shared K. D. Read· 3 shared Z. C. Johnston· 3 shared A. I. Lamond· 2 shared A. Richardson· 2 shared C. L. Barratt· 2 shared

Activity by Year

2017-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCell Biology

C. Wilson

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Sperm Cell Painting: A Mechanism Driven Approach for Drug Discovery in Human Spermatozoa

Z. C. Johnston, F. S. Gruber, R. Myles, S. V. Kane, A. Richardson, D. P. Day, C. Wilson, K. D. Read, I. H. Gilbert, S. Martins da Silva, C. L. R. Barratt, J. R. Swedlow

This paper adapts a cell painting assay to human spermatozoa to create an image-based fingerprint for studying compound effects on sperm function and contraceptive discovery.

bioRxiv · Sep 15, 2023 · PreprintCell Biology

Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

H. Jiang, J. Druker, J. W. Wilson, D. Bensaddek, J. R. Swedlow, S. Rocha, A. I. Lamond

This paper develops a workflow to identify proline hydroxylation sites using HILIC and LC-MS, finding 4,993 and 3,247 sites in HEK293 and RCC4 cells, respectively.

bioRxiv · Jul 28, 2023 · PreprintBiochemistry

Screening for variable drug responses using human iPSC cohorts

M. Platani, H. Jiang, L. Davidson, S. Hariharan, R. Doyonnas, A. I. Lamond, J. R. Swedlow

The paper develops a drug screening platform using hiPSC lines from different donors to predict variable drug responses and mechanisms, showing potential for improving drug safety across diverse genetic backgrounds.

bioRxiv · Jun 16, 2023Cell Biology

Sperm Toolbox - A selection of small molecules to study human spermatozoa

F. S. Gruber, A. Richardson, Z. C. Johnston, R. Myles, N. Norcross, D. Day, I. Georgiou, L. Sesma Sanz, C. Wilson, K. D. Read, S. Martins da Silva, C. L. Barratt, I. H. Gilbert, J. R. Swedlow

The paper establishes a small molecule library for studying human spermatozoa and provides a dataset for comparing compound effects and assays.

bioRxiv · May 2, 2023Pharmacology & Toxicology

Compounds enhancing human sperm motility identified using a high-throughput phenotypic screening platform

F. S. Gruber, Z. C. Johnston, N. R. Norcross, I. Georgiou, C. Wilson, K. D. Read, I. H. Gilbert, J. R. Swedlow, S. Martins de Silva, C. L. Barratt

A high-throughput screening platform identified 105 compounds that enhance human sperm motility, including novel targets like GABA signaling and PDE10A inhibitors.

Human Reproduction · Jan 20, 2022Peer-reviewedPhysiology

Numerically enhanced adaptive optics-based 3D STED microscopy for deep-tissue super-resolved imaging

P. Zdankowski, M. Trusiak, D. McGloin, J. R. Swedlow

This paper introduces a 3D STED microscope with automated aberration correction and BM3D denoising to improve super-resolved imaging through thick tissue.

bioRxiv · Jun 2, 2019Biophysics

The Ndc80 complex targets Bod1 to human mitotic kinetochores

K. Schleicher, S. ten Have, I. M. Porter, J. R. Swedlow

This paper shows that the Ndc80 complex recruits Bod1 to mitotic kinetochores, regulating PP2A-B56 activity and Ndc80 phosphorylation to maintain chromosome-spindle attachments.

bioRxiv · Apr 27, 2017Cell Biology