Author

F. Salgado-Polo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Perrakis· 3 shared W. H. Moolenaar· 2 shared A. Fish· 1 shared A. J. Morris· 1 shared A. Mazzocca· 1 shared A. Menegakis· 1 shared B. Heckmann· 1 shared C. Jagerschmidt· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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3 shared papersCell Biology

A. Perrakis

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Autotaxin facilitates selective LPA receptor signaling

F. Salgado-Polo, R. Borza, F. Marsais, C. Jagerschmidt, L. Waeckel, W. H. Moolenaar, P. Ford, B. Heckmann, A. Perrakis

This study shows that ATX inhibitors targeting the ATX tunnel selectively block LPA signaling via P2Y receptors, with implications for pulmonary fibrosis treatment.

bioRxiv · Apr 9, 2022Cell Biology

Autotaxin impedes anti-tumor immunity by suppressing chemotaxis and tumor infiltration of CD8+ T cells

E. Matas-Rico, E. Frijlink, I. van der Haar Avila, A. Menegakis, M. van Zon, A. J. Morris, J. Koster, F. Salgado-Polo, S. de Kivit, T. Lanca, A. Mazzocca, Z. Johnson, J. Haanen, T. N. Schumacher, A. Perrakis, , W. H. Moolenaar

This study shows that ATX secreted by melanoma cells repels CD8+ T cells, reducing their infiltration into tumors and impairing anti-tumor immunity.

bioRxiv · Feb 26, 2020Cancer Biology

Lysophosphatidic acid produced by Autotaxin acts as an allosteric modulator of its catalytic efficiency

F. Salgado-Polo, A. Fish, M.-T. Matsoukas, T. Heidebrecht, W.-J. Keune, A. Perrakis

The paper investigates how lysophosphatidic acid (LPA), produced by autotaxin (ATX), modulates its own catalytic efficiency through allosteric regulation.

bioRxiv · Jun 13, 2018Biochemistry