Y. Hasegawa

Evolution and diversification of the momilactone biosynthetic gene cluster in the genus Oryza

The paper reconstructs the evolution and sub-functionalization of the momilactone biosynthetic gene cluster in Oryza species using comparative genomics.

Genetic and immune determinants of E. coli liver abscess formation

This study identifies host genetic and immune factors that determine susceptibility to E. coli liver abscesses in mice using spatial and single-cell transcriptomics.

Inhibition of OCT4 Binding at the MYCN Locus Induces Neuroblastoma Cell Death Accompanied by Downregulation of Transcripts with High-Open Reading Frame Dominance

This study shows that inhibiting OCT4 binding at the MYCN locus in neuroblastoma cells reduces MYCN activity, leading to cell death through caspase-2 activation and downregulation of high-ORF dominance transcripts.

Global changes in open reading frame dominance of RNAs during cancer initiation and progression

The paper measures ORF dominance in cancer and finds it increases with carcinogenesis, correlates with translation, and blurs coding/noncoding boundaries before metastasis.

A bile metabolite atlas reveals infection-triggered interorgan mediators of intestinal homeostasis and defense

This study maps bile metabolites in mice, showing how infections alter bile composition and affect intestinal homeostasis and defense.

Pulmonary osteoclast-like cells in silica induced pulmonary fibrosis

The paper investigates silica-induced pulmonary fibrosis in mice, finding that silica triggers osteoclast-like differentiation of macrophages and monocytes, contributing to lung injury and fibrosis.

A single-cell atlas of bobtail squid visual and nervous system highlights molecular principles of convergent evolution

This study uses single-cell transcriptomics to analyze the visual and nervous system of the bobtail squid, revealing novel cell types and molecular mechanisms of convergent evolution in visual systems.

Single-nucleotide substitution determines pollen production in Japanese cedar

This study identifies a single-nucleotide substitution in the TKPR1 gene that determines pollen production in Japanese cedar and suggests its potential application in creating pollen-free plants.

Escaping through the predator's gill cleft: A defensive tactic of juvenile eels after capture by predatory fish

The paper describes how juvenile Japanese eels escape predators by exiting through the predator's gill cleft, with most survivors observed.

TGN/EE SNARE protein SYP61 is ubiquitinated and required for carbon/nitrogen-nutrient responses in Arabidopsis

This study identifies SYP61 as a ubiquitinated SNARE protein in Arabidopsis, showing its role in nutrient stress responses and trafficking.

Cloning of Two Gene Clusters Involved in the Catabolism of 2,4-Dinitrophenol by Paraburkholderia sp. Strain KU-46 and Characterization of the Initial DnpAB Enzymes and a Two-Component Monooxygenase DnpC1C2

This study identifies and characterizes two gene clusters in Paraburkholderia sp. strain KU-46 involved in DNP catabolism, revealing a unique pathway for DNP degradation via 4-nitrophenol.

Preservation of three-dimensional spatial structure in the gut microbiome

This study evaluates embedding methods for preserving three-dimensional spatial structure in mouse gut tissue for fluorescence imaging, finding that Technovit H8100 better preserves spatial organization than common media.