Coordinated regulation of CB1 cannabinoid receptors and anandamide metabolism stabilizes network activity during homeostatic scaling down
Michael Y. Ye, Sarah Monroe, Sean M. Gay, Michael Armstrong, Diane E. Youngstrom, Fabio Urbina, Stephanie L. Gupton, Nichole A. Reisdorph, Graham H. Diering
This study shows that chronic hyperexcitation in cultured neurons triggers homeostatic downscaling and enhances endocannabinoid signaling through coordinated changes in FAAH, anandamide, and CB1.
eNeuro · Oct 31, 2022Peer-reviewedNeuroscience