Stephanie L. Gupton

This study identifies TRIM9 as a sex-specific regulator of the Aβ42/PrPC/mGluR5 complex in male Alzheimer's mice, linking it to pathological signaling and autophagy.

This study shows TRIM9 promotes melanoma proliferation and alters cell morphology by modifying actin organization and adhesion.

This study identifies Coro1A and TRIM67 as collaborators in netrin-dependent neuronal morphogenesis, showing their interaction is required for netrin responses.

This study shows TRIM9 regulates both attractive and repulsive axonal responses to netrin-1 by interacting with DCC and UNC5C in cortical neurons.

This study shows TRIM67 localizes to the post-synaptic density and its loss alters the PSD proteome and cytoskeletal regulation.

This study shows TRIM9 localizes to dendritic spines and regulates actin dynamics and synaptic responses to netrin-1 during synaptogenesis.

This study shows that chronic hyperexcitation in cultured neurons triggers homeostatic downscaling and enhances endocannabinoid signaling through coordinated changes in FAAH, anandamide, and CB1.

This study identifies tSNARE1 as a schizophrenia risk gene that regulates endolysosomal trafficking in cortical neurons through its isoforms' effects on endosomal cargo movement.

This study shows that TRIM67 is critical for brain development and behavior, with deletion causing anatomical and functional impairments in mice.