Trans-Translation inhibitors and copper ions synergize for enhanced antibiotic activity
Melissa Vázquez‐Hernández, Huriye Deniz Uzun, Mona Otte, Lea Schipp, Christoph Helmut Rudi Senges, Sascha Heinrich, John N. Alumasa, Jennifer Stepien, Fatih Demirbas, Paolo Cignoni, Katrin Marcus, Kristina Tschulik, Ute Kraemer, Thomas Günther Pomorski, Kenneth C. Keiler, Julia Elisabeth Bandow
This paper shows that trans-translation inhibitors KKL-40 and KKL-55 synergize with copper ions to enhance antibacterial activity against B. subtilis by causing rapid translation stalling and preventing copper toxicity response.
bioRxiv · Nov 14, 2024 · PreprintMicrobiology