Revealing the unexpected interplay between the Proteasome Activator PA200 and the immunoproteasome
Dušan Živković, Fatme Mourtada, Angélique Sanchez Dafun, Ayse Seda Yazgili, Marijke Jansma, Przemysław Grygier, Michał Rawski, Anna Czarna, Stefan Bohn, Krzysztof M. Żak, Norbert Reiling, Linda Zemke, Kai Guo, Jürgen Behr, Odile Burlet‐Schiltz, , Marie‐Pierre Bousquet
This paper reveals structural and functional differences in PA200 interaction with the immunoproteasome (i20S) compared to the standard proteasome (s20S), showing PA200 enhances i20S activation and regulates its gene expression.
bioRxiv · Mar 18, 2025 · PreprintBiochemistry