This paper reveals structural and functional differences in PA200 interaction with the immunoproteasome (i20S) compared to the standard proteasome (s20S), showing PA200 enhances i20S activation and regulates its gene expression.

bioRxiv · Mar 18, 2025 · PreprintBiochemistry

Phosphoproteomics of cellular mechanosensing reveals NFATC4 as a regulator of myofibroblast activity

Laura F. Mattner, Zhen Zeng, Christoph H. Mayr, Meshal Ansari, Xin Chuan Wei, Sara Asgharpour, Anita A. Wasik, Nikolaus Kneidinger, Mircea-Gabriel Stoleriu, Jürgen Behr, Julien Polleux, Ali Önder Yildirim, Gerald Burgstaller, Matthias Mann, Herbert B. Schiller

This study identifies NFATC4 as a regulator of myofibroblast activity through phosphoproteomic analysis of fibroblast mechanosensing on stiffness-modulated substrates.

bioRxiv · Feb 13, 2023 · PreprintSystems Biology

Longitudinal single cell transcriptomics reveals Krt8+ alveolar epithelial progenitors in lung regeneration

Maximilian Strunz, Lukas Mikolaj Simon, Meshal Ansari, Laura F. Mattner, Ilias Angelidis, Christoph H. Mayr, Jaymin J. Kathiriya, Min Yee, Paulina Ogar, Arunima Sengupta, I. V. Kukhtevich, Robert Schneider, Zhongming Zhao, Jens H. L. Neumann, Jürgen Behr, , Herbert B. Schiller

The paper uses single-cell RNA-seq to identify Krt8+ progenitor cells involved in lung regeneration and shows their role in epithelial differentiation and disease.

bioRxiv · Jul 18, 2019 · PreprintSystems Biology