Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson disease
Jiasong Pan, Lu Geng, Xuehe Liu, Yinglei Wang, Ning Fang, Feiyan Xie, Yajie Shen, Yifan Deng, Yuyun Han, Suhua Li, Wenyong Xiong, Hua He, Ning‐Yi Shao, Jian Wang, Jixi Li
This paper identifies GSDME as a mediator of neurodegeneration in Parkinson's disease by linking mitochondrial damage to pyroptotic cell death through caspase-3 activation.
bioRxiv · Dec 16, 2025 · PreprintNeuroscience