Jian Wang

This paper identifies GSDME as a mediator of neurodegeneration in Parkinson's disease by linking mitochondrial damage to pyroptotic cell death through caspase-3 activation.

The paper examines early-onset β-amyloidosis in brains with hematological malignancies and cardiovascular diseases, finding vascular injury and axonal pathology associated with Aβ formation.

This study shows that reduced BAG3-mediated autophagy leads to tau accumulation, contributing to neurodegeneration in Drosophila models of CAG and GGGGCC repeat expansions.