Author

Yajie Shen

Fudan University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Microbiology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Jixi LiiD· 3 shared Lu GengiD· 3 shared Jiasong Pan· 2 shared Xiao‐Yong FaniD· 2 shared Xuehe Liu· 2 shared Yifan DengiD· 2 shared Yuxin QiuiD· 2 shared Zhidong HuiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersMicrobiology

Jixi LiORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination

Yajie Shen, Yifan He, Xuehe Liu, Anke Chen, Lu Geng, Xuehe Liu, Yuhui Gao, Yuxin Qiu, Lu Zhang, Zhidong Hu, Yicheng Sun, Sheng‐ce Tao, Xiao‐Yong Fan, Hua Yang, 戈宝学, , Jixi Li

This study identifies EccB5 as a key Mtb effector that drives pyroptosis and enhances virulence by interacting with GSDMD and caspase-1.

Cell Death and Differentiation · Oct 28, 2026Peer-reviewedMicrobiology

Gasdermin E couples mitochondrial damage to pyroptotic neurodegeneration in Parkinson disease

Jiasong Pan, Lu Geng, Xuehe Liu, Yinglei Wang, Ning Fang, Feiyan Xie, Yajie Shen, Yifan Deng, Yuyun Han, Suhua Li, Wenyong Xiong, Hua He, Ning‐Yi Shao, Jian Wang, Jixi Li

This paper identifies GSDME as a mediator of neurodegeneration in Parkinson's disease by linking mitochondrial damage to pyroptotic cell death through caspase-3 activation.

bioRxiv · Dec 16, 2025 · PreprintNeuroscience

RING1 dictates GSDMD-mediated inflammatory response and host susceptibility to pathogen infection

Yuanyuan Li, Wenqing Gao, Yuxin Qiu, Jiasong Pan, Qingqing Guo, Xuehe Liu, Lu Geng, Yajie Shen, Yifan Deng, Zhidong Hu, Suhua Li, Shanshan Liu, Adi Idris, Jinqing Huang, Hua Yang, , Jixi Li

This study shows RING1 suppresses pyroptosis by ubiquitinating GSDMD, reducing inflammation and pathogen susceptibility in mice.

Cell Death and Differentiation · May 14, 2025Peer-reviewedCell Biology