Microglial cannabinoid receptor type1 mediates social memory deficits produced by adolescent THC exposure and 16p11.2 duplication
Yuto Hasegawa, Juhyun Kim, Gianluca Ursini, Yan Jouroukhin, Xiaolei Zhu, Yu Miyahara, Feiyi Xiong, Samskruthi Madireddy, Mizuho Obayashi, Beat Lutz, Akira Sawa, Solange Pezon Brown, Mikhail V. Pletnikov, Atsushi Kamiya
This study shows that adolescent THC exposure causes microglial apoptosis in the mPFC, which is worsened by 16p11.2 duplication, leading to social memory deficits via microglial Cnr1.
bioRxiv · Jul 24, 2023 · PreprintNeuroscience