Hallmarks of adaptive immunity in a metastatic clear cell renal cell carcinoma (ccRCC) long-term elite survivor
Felicia Tucci, Edward Drydale, James M. Bancroft, Sakina Amin, Jane I. Pernes, Giulia Gardumi, Tinashe Kanyowa, Maria Lima, Nadia Nasreddin, Olivia Lombardi, Simon John Leedham, Aniko Rendek, Lisa Browning, Emmanuel Bugarín-Estrada, Ruddy Montandon, , Rachael J. M. Bashford-Rogers
This study identifies clonal persistence, tertiary lymphoid structures (TLS) engagement, and coordinated B-T cell immune surveillance as hallmarks of durable tumour control in a long-term survivor of metastatic ccRCC.
bioRxiv · Dec 22, 2025 · PreprintCancer Biology