Author

Lauren Overend

Centre for Human GeneticsORCID 0000-0002-2802-048XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1

Frequent Co-Authors

Adam Frampton· 1 shared Alex Nicolas Gordon-WeeksiD· 1 shared Carl LeeiD· 1 shared Caroline MorrelliD· 1 shared Catherine SutherlandiD· 1 shared Emma E. DavenportiD· 1 shared Emma Louise CulveriD· 1 shared Felicia Tucci· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperSystems Biology

Adam Frampton

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2 papers

Recent·Most cited

Single-cell level characterization of B cell depletion and repopulation following rituximab in systemic lupus erythematosus

Haerin Jang, Norzawani B Buang, Catherine Sutherland, Wanseon Lee, Lauren Overend, Tarran S. Rupall, Katie L. Burnham, Matthew Caleb Pickering, Marina Botto, Emma E. Davenport

This study uses single-cell profiling to track B cell depletion and repopulation in SLE patients after rituximab treatment, revealing changes in B cell subsets and immune cell dynamics.

Arthritis & Rheumatology · Mar 8, 2026Peer-reviewedGenetic & Genomic Medicine

SpatioEv: Spatial evolution of protein and morphological features reveals development dynamics of cells and spatial neighbourhoods

Shihong Wu, Sakina Amin, Carl Lee, Jean-Baptiste Richard, Nabeel Merali, Caroline Morrell, Lauren Overend, Wei Gao, Felicia Tucci, Alex Nicolas Gordon-Weeks, Adam Frampton, Nicola E. Annels, Emma Louise Culver, Michael Loran Dustin, Kim S. Midwood, Rachael J. M. Bashford-Rogers

SpatioEv analyzes spatial data to reveal cell and neighborhood dynamics, identifying disease-specific spatial signatures and developmental trajectories in tissues.

bioRxiv · Jun 30, 2025 · PreprintSystems Biology