Hepatic GCGR is required for the superior weight loss effects of a structurally related analogue of the dual GCGR/GLP1R agonist survodutide
Fen Long, Tenagne D. Challa, Vissarion Efthymiou, Manuel Klug, Thomas Klein, Heike Neubauer, Christian Wolfrum, Carla Horváth
The paper shows that hepatic GCGR is essential for the enhanced weight loss and lipid clearance effects of a dual GCGR/GLP1R agonist compared to a selective GLP1R agonist.
Diabetes Obesity and Metabolism · Dec 12, 2025Peer-reviewedPhysiology