Author

Tenagne D. Challa

ETH ZurichORCID 0000-0002-5898-8061Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1 Organism:mouse· 1

Frequent Co-Authors

Anne GoergeniD· 1 shared Carla HorváthiD· 1 shared Carlos Villarroel-VicenteiD· 1 shared Christian WolfrumiD· 1 shared Daniel KonradiD· 1 shared Fen Long· 1 shared Heike NeubaueriD· 1 shared Manuel Klug· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperPhysiology

Anne GoergenORCID

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2 papers

Recent·Most cited

PhysiologyDiabetes Obesity and MetabolismPeer-reviewedDec 12, 2025

Hepatic GCGR is required for the superior weight loss effects of a structurally related analogue of the dual GCGR/GLP1R agonist survodutide

Fen Long, Tenagne D. Challa, Vissarion Efthymiou…·Carla Horváth

The paper shows that hepatic GCGR is essential for the enhanced weight loss and lipid clearance effects of a dual GCGR/GLP1R agonist compared to a selective GLP1R agonist.

3 citations

humanexperimental assay

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PhysiologybioRxivPreprintJan 23, 2025

ASK1 overexpression protects from HFD-induced body weight gain via FGF21

Anne Goergen, Tenagne D. Challa, Marcela Borsigova…·Daniel Konrad

This study shows that liver-specific ASK1 overexpression protects against HFD-induced obesity and improves glucose metabolism via increased FGF21 production.

DOI 10.1101/2025.01.23.634369

mouseexperimental assay

𝕏 PostBluesky